CHATFIELD PHARMACEUTICALS LTD JOB SCAM

We are pleased to offer you the position of QUALITY CONTROL MANAGER as discussed by us, you are requested to join us on 25th of July 2015, if there is any change in the date of joining, changes can be taken under consideration.

The roles and responsibilities and other terms and conditions of your employment has been specified in your letter of appointment, kindly find attached. On this note, we hereby congratulate you on the success of your application and as such we have attached to you the Offer Letter/Terms of Agreement that transcends any written document.

It is expected that you join us as early as possible but not later than one (1) Month, beyond which the offer would be in abeyance, until a new date may be considered by us.On acceptance of this Appointment you are to submit the following referenced documents below to us:

***Scanned copy of your duly Signed Acceptance Letter.
***Scanned Copy of International Passport (Data Page).
***Scanned Copy of Passport Photograph (Coloured).
***Scanned Workers Registration Certificate and National Insurance Number

This Offer of Expatriate Work contract is contingent upon the fulfillment of all the above referenced engagement provisions within the time frame allotted to it. Kindly,acknowledge the receipt of this offer and if acceptable to your expectation, sign the agreement copy as a token of your acceptance and return same to us within Four (4) days of acceptance.You shall be eligible to receive the benefits/compensations indicated in the main terms and Conditions which shall include:

* Health/life and disability insurance.
* Sick leave
* Vacation days  
* Allowances
* Car/travel and telephone expenses
* Other Normal and reasonable expenses will be reimbursed on a monthly basis per company policy.
* Bonus effective upon your completion of 90 days of employment, and based on the formula determined by the Company.

You are required to contact the HUDSON LEGAL SOLICITORS whose contact details are given below for expedited processing of your Workers Registration Certificate and National Insurance Number that must be presented to us within Ten Days of receipt of this offer letter as an indication of your readiness to resume with the Company.

HUDSON LEGAL SOLICITORS
Name: Mr. David Leon
Designation: Principal Notary
Tel: +44 (0) 7045784488
Email: enquiry@hudsonimmigrationsolicitors.com    
Alt email: hudsonlegalsolicitors@gmail.com
Website: www.hudsonimmigrationsolicitors.com 

Note, failure to provide the Workers Registration Certificate and National Insurance Number On or before the 25th May 2015, could be considered to mean your lack of readiness to resuming with the company and unwillingness to abide with UK Public/work safety Guideline, and will result to the nullification of the Appointment.

Note that it is your duty to bear the cost of your Workers Registration Certificate and National Insurance Number as this will enable the company (Chatfield Pharmaceuticals Ltd) to sponsor your Visa,Works/Residence Permit Papers and other traveling material, including your flight ticket and one month upfront salary for you to settle your local expense before your embark on your trip to United Kingdom.


For further clarification regarding your appointment with us, you are advised to contact the HR Manager's office through and also, all the mentioned documents in the appointment letter should be forwarded specifically to:

CHATFIELD PHARMACEUTICALS LTD
Name: Mr. Paul Stanton
Designation: HR/Operations Manager
Telephone: +44 7087628692
Telephone: +44 7042061665
E-mail: hrd@chatfieldpharmaceuticals.com 
Email: info@chatfieldpharmaceuticals.com
Website: www.chatfieldpharmaceuticals.com

Any expenses involved in the processing of the Workers Registration Certificate and National Insurance Number and other contingency  will be reimbursed by the Company after five working days including One (1) month upfront salary to enable you to settle your local expenses before you embark on your trip to United Kingdom on Employee's early notification and substantiated with an official receipt of expense.

We welcome you to Chatfield Pharmaceuticals Ltd family and hope it would be the beginning of a long and mutually beneficial association.


Yours truly,

Mr. Derrick Norman
Recruitment Manager
Chatfield Pharmaceuticals Ltd
Address: Kramer Mews, 
310,Old Brompton Rd, London,
SW5 9JQ United Kingdom.
Email: careers@chatfieldpharmaceuticals.com

SHOPQUIKR.COM - 100% FAKE

100% fake   100% fake  100% fake  100% fake        100% fake

Shopquikr.com website is 100% fake. Don’t purchase anything from this web site. They will offer you mind blowing offers circulated through mails like 70% discount, 60% discount …etc.

Don't get in the trap of cloned mobiles from china. And you can find their contact details like below but no body will respond.

CALL US AT

+91- 9266633226

Mail To:support@shopquikr.com

See some example from their website.

They have mentioned only iPhone 6 and not mentioned any where apple. If you call them they will say its original apple brand iPhone 6.  And also they will say these offers are due to first anniversary of their website.

But if you look in to these offers keenly you will find the below pages. And just notice the clone word in the website link of these offers at address bar. So they are selling cloned duplicate mobiles in the name of iPhone 6.

                               

Once you ordered, nobody will respond you. And if any customer care people attended the call they say your mobile will come tomorrow every time. After one month they will send duplicate one and you will feel like at least I got this.

Don’t be a fool by purchasing from this fake website. Don’t get tempted to others offers like this.

Now offer on galaxy note 4 is going on to attract people.

Totally its 100% fake website, they will send all china made items which are priceless.

LEARN ENGLISH - USAGE OF 'GOING TO'

Future లో జరుగబోతున్న పనులు, మనం ముందే అనుకొని కచ్చితంగా చేయబొయే పనులకు  am going to / is going to/ 1st regular doing words వాడతాం

भविष्य में जो कार्य होने वाले हैं, उन चीजों के लिए जो हम आशा करते हैं और करते हैं am going to / is going to/ 1st regular doing words उपयोग करेंगे।

EX:
1. She is going to buy a new car.
2. They are going to withdraw all the money from bank.
3. I am going to start a new political party.

:::: will / shall కంటె going to ఎక్కువ ఖచ్చితం.
      will / shall से going to अधिक सटीक।

Ex:
1. I will buy a car soon. 
    నేను కారు కొనాలని నిశ్చంచుకున్నను

    मैं जल्द ही एक कार खरीदूंगा।

2. I am going to buy a car
    నేను వీలైనంత త్వరలొ కారు కొంటా. ఖచ్చితం ఎక్కువ.
    मैं एक कार खरीदने जा रहा हूं. सटीकता अधिक है

DIFFERENCE BETWEEN PROFESSION AND BUSINESS

One day I asked one my friend about his business and he told me he was a banker then I asked him if you own the bank? And he usually respond “no I work there”. In this instance my friend confused his profession with business.

One day Ray Kroc, The founder of McDonalds was asked MBA students at the University of Texas at Austin, “What business am I in?”

Everyone laughed and no one answered, and finally one brave boy yelled out, Ray who in the world does not know that you are in the Hamburger business.”

Ray laughed, “That’s what I thought you would say.” He continued “Ladies and gentleman I’m not in the hamburger business and my business is real estate. My primary business focus was to sell hamburger franchises but what i never lost sight of the location of each franchise. The person that bought franchise was also paying for land under the franchise.

Hence so there is a lot of difference between business and profession. Generally people spend their lives minding someone else’s business and making that person rich. But actually to become financially secure person need to mind their own business.

The primary reason the majority of the poor and middle class are fiscally conservative-which means “I can’t afford to take risks- is that they have no financial foundation. They have to cling to their jobs. They have to play it safe.

Many people think that what business they can do as they cling to their jobs. But where there is a will there is a way. See some of below mentioned practically possible business

1. You can do the business that do not require your presence. You own them, but they are managed or run by other people. If I have to work there, it’s not a business. It’s become your job.

2. Income generated real estate.

3. Stocks, Bonds and mutual bonds.

4. Life insurance policies 

5. Blogging, affiliates, AdSense

Above mentioned are few examples if you think seriously you will get number of options. So start minding your own business.

I would not encourage anyone to start a company or invest in share market unless you really want to do it after attaining sufficient knowledge. When I say mind your own business, I mean to build and keep your assets strong.

TAKE RISK

IF YOU WIN YOU WILL BE HAPPY

IF YOU LOOSE YOU WILL BE WISE

Copied from Rich dad poor dad book.

HR INTERVIEW QUESTION

Even though you have an excellent knowledge on technical aspects and cleared the technical round, you may not selected until you pass HR interview. 

To clear HR interview you should have political approach while answering the question. Find below questions with possible best answers. 

1) TELL ME ABOUT YOUR SELF?
Follow the below format to describe yourself.
1. Name
2. Educational details (starting from higher).
3. Experience with work profile.
4. Professional strength.
5. Technical knowledge.
6. Positives.
7. Negatives.
8. Family details

(And conclusion is) If you consider my education & experience, I think i am suitable to your job.

2) WHY SHOULD I SELECT YOU? (or) WHY SHOULD I CHOOSE YOU?
First of all, I am sure i have the all eligibilities that match your job. Apart from the eligibilities, there are many reasons but to be very specific my USP is hard work, enthusiastic to learn, passionate to do work, which matches your job profile.

3) WHY ARE YOU LEAVING THE PRESENT JOB? (or) WHY DID YOU LEAVE THE LAST JOB?
That was a good job and had nice colleagues there. No doubt about it. But according to me we cannot grow in the field without taking more responsibilities & risks and also we can't enhance our skills (like team leading capabilities and Managerial skills) without expose to wide range of people. I think it’s time for me to grow and enhance my skills. And also I need some salary hike to make my life some more beautiful.

4) WHAT ARE YOUR WEAKNESSES?
Well, my presentation skills are not the best one. But I read a lot of literature and regularly practice to improve it. And it was much better as it was one year back.

5) WHAT IS YOUR SALARY EXPECTATIONS?
Salary is not the first priority for me I applied for this job because I really like the role your offer. I know if I work well and achieve good results salary will automatically meet my expectations.

6) WHERE DO YOU SEE YOUR SELF IN FIVE YEARS?
I hope to be working in your company as manager, achieving great results in my department in 5 years time.

INTERVIEW QUESTIONS ON SYSTEM SUITABILITY PARAMETERS - HPLC & GC

1) WHAT IS SYSTEM SUITABILITY TEST? EXPLAIN SST PARAMETERS IN HPLC or GC?

The system suitability test is used to verify that the chromatographic system is suitable for the intended analysis or not. That is to ensure that the complete testing system including instruments, electronics, reagents, column & analyst is suitable for intended application.

The main system suitability parameters are
1. Precision
2. Capacity factor
3. Selectivity factor
4. Resolution
5. Theoretical plate count
6. Tailing factor
7. Signal to Noise ratio
8. Peak to valley ratio

2) WHAT IS PRECISION? EXPLAIN?
It is the closeness with which results of replicate analysis of a sample agree. Usually expressed in terms of %RSD.
%RSD = Standard Deviation*100/Mean.

For Assay by HPLC, the maximum permitted relative standard deviation does not exceed the appropriate value given in the below table as per USP & EP.

Note:

1.B (percent) means upper limit of your assay -100.
That is If your assay limit is 98%-102%, B (percent) is 102%-100% = 2.0
That implies your %RSD should not more than 0.85% for 6 injections and 0.73 for 5 injections.

2.This requirement does not apply to tests for related substances.

3) WHAT IS CAPACITY FACTOR or RETENTION FACTOR?
It is the ratio of the adjusted retention volume (or time) to the hold-up or Void volume (or time). (or) It is the migration rate of analyte on a column (or) It is a measure of time of sample component resides in the stationary phase relative to the time it resides in the mobile phase.

Simply it is measure of where the peak of interest located with respect to void volume (retention volume of unretained compound).

Capacity factor (K¹) = VR¹/Vm = tR¹/ tm = (tR-tm)/tm

VR¹= Retention volume of analyte.
VM=Retention volume of unretained compound
tR=Retention time of analyte.
tm or to=Retention time of unretained compound

Note:
1. Generally the ideal valve of K¹ is in between 2 to 5. But the acceptable valve is in between 1 to 20 .

4) WHAT IS SELECTIVITY FACTOR or RELATIVE RETENTION? EXPLAIN?
The relative retention of two peaks in a column is known as selectivity factor. It is the ratio of adjusted retention time of a compound to that of another used as reference obtained under identical conditions.

Selectivity factor (a ) = K2/K1 = (tR2-tm)/ (tR1-tm)

tR2=Retention time of our analyte
tR1=Retention time of reference compound.

Note:
1. As per USP the selectivity factor should be always greater than 1.

5) WHAT IS RESOLUTION? EXPLAIN?
Resolution is the ratio of distance of separation of band maxima to their average base width. (or) The distance between the peak centers of a two analyte peaks divided by the average base width of the peaks.

“It is the ability of a chromatographic column to separate peaks. It is usually expressed in terms of the separation between two adjacent peaks”

As per USP:


Resolution(R) = 2 (tR2-tR1)/ (w1+w2)

tR2&tR1 are retention times of two components.

w1&w2 are corresponding peak widths at base.

As per EP:

Resolution(R) = 1.18 (tR2-tR1)/ (wh1+wh2)

tR2&tR1 are retention times of two components

wh1&wh2 are corresponding peak widths at half height.

Note:
1. Base line resolution achieved at R=1.5. But more than two is desirable.
6) WHAT IS THEORITICAL PLATE? HOW NUMBER OF THEORITICAL PLATES EFFECT THE COLUMN EFFICIENCY? EXPLAIN?

Martine & Synge used a chromatographic model involving a hypothetical division of column in to no. of plates known as theoretical plate. So, Theoretical plate is an imaginary part of the column.

The theoretical plate number (N) is a measure of the efficiency per unit length of the column.

As per USP:


Number of theoretical plates (N) = 16 (tR/W) 2

tR=Retention time of analyte

W=Peak width at base

As per EP:

Number of theoretical plates (N) = 5.54 (tR/Wh) 2

tR=Retention time of analyte

Wh =Peak width at half height.

7) WHAT IS SYMMETRY FACTOR or TAILING FACTOR? EXPLAIN?

1. Theory assumes an ideal symmetric peak which is known as Gaussian peak. The front side deviation from the Gaussian peak is known as peak fronting & rear side deviation is known as peak tailing.

2. It is a factor which describing shape of a chromatographic peak. And it is a measure of peak tailing.

Define Tailing factor:

“the distance from the front slope of the peak to the back slope divided by twice the distance from the center line of the peak to the front slope, with all measurements made at 5% of the maximum peak height”.
As per USP & EP:

Tailing factor (As) = w 0.05/2d

w 0.05=Width of peak height at one-twentieth of peak height

d=Distance between the perpendicular dropped from the peak maxima and the leading edge of the peak at one-twentieth of the peak height

Note:
1. As per EP, In related substance test or assay the symmetry factor should be in between 0.8 to 1.5 unless otherwise specified prescribed.


8) WHAT IS SIGNAL TO NOISE (S/N) RATIO? EXPLAIN?

The short term noise influences the precision of quantification. So S/N ratio is a useful system suitability parameter to identify noise effect on quantification of impurities..etc.

Signal to noise(S/N) ratio is calculated from following equation


S/N = 2H/h

Where

H= Height of concerned peak measured from the peak apex to the base extrapolated over a distance ≥5 times the peak width at its half height.

h= Difference between the largest and smallest noise valves observed over a distance ≥5 times width at half height of the peak.




9) WHAT IS PEAK TO VALLEY (p/v) RATIO EXPLAIN?

Peak to valley (p/v) ratio may be employed as system suitability criterion in a test for related substance when baseline separation between two peaks is not achieved.

p/v = Hp/Hv Where

Hp= Height above the extrapolated baseline of the minor peak.
Hv= Height above the extrapolated baseline at the lowest point of the curve separating the minor and major peaks.

QUALITY CONTROL INTERVIEW QUESTIONS ON CHROMATOGRAPHY

       1)WHAT IS THE PRINCIPLE OF CHROMATOGRAPHY (HPLC&GC)?

Separation of, mixture of components, Based on equilibrium distribution of analyte between two immiscible phases (like stationary phase and mobile phase).

HPLC: Solid stationary phase, Liquid mobile phase

GC     : Liquid stationary phase, Gas mobile phase.

       2) WHAT ARE REVERSE PHASE AND NORMAL PHASE CHROMATOGRAPHY?

These are the different type of techniques in chromatography.

Reverse phase chromatography:

Stationary phase: Non-polar

Mobile phase      : Polar

Normal phase chromatography:

Stationary phase: Polar

Mobile phase      : Non-polar

       3)IS CHIRAL CHROMATOGRAPHY & NORMAL PHASE CHROMATOGRAPHY ARE SAME or NOT?

No both are not 100% same.

Chiral chromatography:

             In this we determine the content of chiral isomer whether is it in normal phase or in reverse phase.

Normal phase chromatography:

             In this as above said we must use polar stationary phase and non-polar mobile phase whether is it to determine content of isomer or purity of analyte or whatever it may be.

       4) WHAT IS THE DIFFERENCE BETWEEN CHROMATOGRAPHIC PURITY & RELATED SUBSTANCE BY HPLC?

Chromatographic purity:

              Chromatographic purity is used when all the impurities are known in the given sample. Here we quantitate only known impurities.

Related substance:

               Related substance is used to quantitate both known as well as unknown impurities in the given sample.

       5)         WHAT ARE THE IMPURITY QUANTITATION METHODS IN HPLC?

There are mainly four types.

      1.      Area normalization method

      2.      Internal standard method

      3.      External standard method

      4.      Standard addition method

       6)  WHAT IS THE DIFFERENCE BETWEEN HPLC PURITY, ASSAY AND POTENCY?

Purity:

            It explains how pure our analyte is. It is not related to the amount of analyte present. Simply it is “100-% known or unknown impurity detected in HPLC”

Assay:

           It explains how much of our analyte is (i.e. content of our analyte). It is not related to purity of our analyte.

Potency:

           It explains how potent our analyte is (i.e. the original content of our analyte). It is calculated by mass balance technique. Simply it is 100-all possible impurities.

All possible impurities include Chromatographic impurities (HPLC, GC, and TLC), Heavy metals, Sulphated ash, MC, LOD etc.

Explanation:

            Let us assume an analyte of A with 99.5% purity, 100% assay and 99.0% potency. Then prepare 20%, 50% and 85% solution and analyze in HPLC.

For 20% solution you will get 99.5% purity, 20% assay and 99.0% potency.

For 50% solution you will get 99.5% purity, 50% assay and 99.0% potency.

For 85% solution you will get 99.5% purity, 85% assay and 99.0% potency.

Because we are diluting the concentration so purity will never change for dilution.  Potency is calculated from purity so it is also remains same.

       7)  WHAT IS A BUFFER SOLUTION? CAN YOU EXPLAIN ABOUT ACIDIC BUFFER & BASIC BUFFER?

Buffer solution:

          A solution which can resist change in its pH value on dilution or on the addition of solution of acid or base (Whole pH remains constant) is known as buffer solution.

Acidic buffer:

         Mixture of equimolar quantities of weak acid and salt of this weak acid with a strong base is known as acidic buffer.

Ex: Mixture of CH3COOH & CH3COONa

Basic buffer:

          Mixture of equimolar quantities of weak base and salt of this weak base with a strong acid is known as basic buffer.

Ex: Mixture of NH4OH & NH4Cl

       8)WHAT ARE PROTIC & APROTIC SOLVENTS?

Protic solvents:

              Any molecular solvent which contain dissociable H⁺ ion is called Protic solvent.

(The molecules of such solvents can donate an H⁺  proton.

Aprotic solvents:

              Any molecular solvent which does not contain dissociable H⁺ ion is called Aprotic solvent. (The molecules of such solvents cannot donate an H⁺  proton).

       9) WHAT IS DIFFERENCE BETWEEN HPLC & GC?

Principally both are same. Both are used for the separation of components present in the mixture of sample. Even though these two are principally same, these two also have some differences based applicability, Instrumentation.

Based on applicability:

·         HPLC is used for the separation of thermally stable (or non volatile) compounds.

·         GC is used for separation of volatile (thermally stable) compounds.

In nature 80% of the compounds are non volatile so we use HPLC more frequently than GC.

            Based on instrumentation:

·         In HPLC we use liquid mobile phase and solid stationary phase (Adsorption technique). And in HPLC we use small columns (more frequently up to 30 cm).

·         In GC we use gas mobile phase and liquid stationary phase (Partition technique). And in GC we use columns of length up to 105 cm.

Mobile phase, stationary phase, column, Detector...etc have to select based on sample properties in both the cases.

·         In HPLC we have the pumping system to pump the mobile phase with somewhat high pressure. But in GC we have no pumping system.

·         In HPLC we cannot change the column temperature with time. But we can change temperature with time in GC by giving oven program.

·         In HPLC we use detectors like UV, RI...etc where as in GC we use FID, ECD...etc.

10)  WHAT IS PHASE COLLAPSE? (or)

 CAN I WASH MY HPLC REVERSE PHASE COLUMN WITH 100% WATER?

Before going to this question we should know the C18 column structure. In HPLC C18 column the inner wall of the column is packed with silica (Si-o-Si), this silica is bonded to C18 linkages.

So from this we can clearly understand that our washing solvent will flow on to C18 linkages.

If we wash our Reverse phase C18 column with 100% water, Due to polar (water) and non polar (C18 linkage) repulsion stationary phase matrix collapsed. This collapse is known as PHASE COLLAPSE. So we should not wash our reverse phase column with 100% water.

11)  WHAT IS NEEDLE WASH IN HPLC? (or)

 WHAT IS THE BEST COMPOSITION FOR NEEDLE WASH?

           The needle wash is used to clean the injector needle before and after the injection. The design of needle in the injector system varies for different manufacturers.

In some designs the inside of the needle is part of the flow path of the mobile phase and thus it is flushed continuously by the mobile phase between injections. In this case it is outside (upper layer) of the needle which is cleaned by the needle wash. In some other designs needle is separate from mobile phase flow path and thus the needle wash is used to clean inside and outside of the needle.

         In all the cases composition of needle wash needs to be matched to the sample since this is what you want to clean off the needle. Therefore typically the composition of needle wash is that which matches the proportion of aqueous and organic solvents in the mobile phase will be appropriate.

12)  WHAT IS SEAL WASH IN HPLC? (or)

 WHAT IS THE BEST COMPOSITION FOR SEAL WASH?

Before going to this question first of all we should know about seal in HPLC. In HPLC pump system there is a piston which moves back and forward in the pump head which drawing in and pushing out the mobile phase with each movement. Since it is a moving part, a seal around this piston is required to prevent mobile phase leaking out of the back of the pump, over a period of time small amounts of mobile phase solvents leach through the seal to the back of the piston. If these solvents contain buffers then the salts may precipitate out forming deposits, which can shorten the life of the seal.

So seal wash is to flush the back of the piston seals to remove any deposits and maximizing the lifetime of the seal.

Composition:

It should be aqueous to dissolve buffer and a small amount of organic is required to prevent the bacteria growth and also to reduce the surface tension of water. Typically seal wash composition is 90% water and 10% organic solvent. The organic solvent may be methanol, acetonitrile and IPA…etc.

13)  IN REVERSE PHASE CHRMATOGRAPHY PEAKS ELUTE EARLIER WHEN WE INCRESE ACETONITRILE.WHY?

Most of people confused that, Water is more polar than acetonitrile so when we increase % acetonitrile peaks should elute late because in reverse phase chromatography more polar one comes out first and non-polar comes out last.

In any chromatography the elution order of analyte depends on eluting strength of solvent. In reverse phase chromatography, the less polar, the greater the eluting strength. So the % of ACN increases the eluting strength also increases so the peaks elute earlier. Reverse is true for normal phase chromatography.

Note:

            1.      In above case except %ACN, remaining all same in both the cases.

14)  WHAT ARE DETECTORS USED FOR GAS CHROMATOGRAPHIC ANALYSIS? NAME AT LEAST 5?

     1.      Flame ionization detector.(FID)

     2.      Electron capture detector.(ECD)

     3.      Thermal conductivity detector.(TCD)

     4.      Photo ionization detector.(PID)

     5.      Flame photometric detector.(FPD)

     6.      Nitrogen-Phosphorous detector.(NPD)

15)  GIVE ICH LIMITS OF FOLLOWING MENTIONED SOLVENTS IN % W/W?

      1.      1,4-Dioxane (Class 2) – 380 ppm

      2.      Cyclo hexane (Class 2)  – 3880 ppm

      3.      Pyridine (Class 2) – 200 ppm

      4.      Xylene (Class 2) – 2170 ppm